Mesotherapy – An Overview of Its Effects, Procedure, and Benefits
Our skin tells our story—but over the years, environmental factors, stress, and the natural aging process can take their toll. In aesthetic medicine, mesotherapy offers a gentle yet effective way to regenerate the skin from the inside out, restoring its freshness and elasticity.
The targeted microinjection of beneficial active ingredients such as hyaluronic acid, vitamins, minerals, and amino acids stimulates cell activity and improves the skin’s structure over the long term.
Whether on the face, neck, décolletage, or hands—mesotherapy is versatile and helps enhance your natural radiance without the need for surgery.
In this article, you’ll learn everything you need to know about the treatment, its benefits, the procedure, and real-life experiences—so you can decide whether mesotherapy is right for you.
What is mesotherapy?
Mesotherapy is a minimally invasive treatment method developed in the 1950s by the French physician Dr. Michel Pistor. Its goal is to deeply revitalize the skin and promote cell regeneration through targeted microinjections of highly effective substances directly into the middle layer of the skin (known as the mesoderm).
In this process, custom-formulated combinations of active ingredients—such as hyaluronic acid, vitamins, amino acids, minerals, and antioxidants—are injected with pinpoint precision. This ensures that the ingredients reach the exact layers of the skin where they can be most effective—significantly deeper than conventional creams or serums could ever penetrate.
What active ingredient is used in mesotherapy?
At Kalia Lab, we use the innovative product NCTF 135 HA, which contains 55 highly effective ingredients that specifically stimulate collagen production, strengthen the skin’s structure, and promote greater elasticity, hydration, and a natural glow.
The high-quality formulation of NCTF 135 HA
- Hyaluronic acid (5 mg/ml): Binds large amounts of water, supports cell regeneration, and helps form new blood vessels—for improved skin elasticity and a fresher appearance.
- 13 Vitamins: Vitamin A promotes cell renewal, vitamin B regulates fatty acid metabolism, and vitamin C stimulates collagen and elastin production.
- 6 minerals: Essential for enzymes, hormones, and maintaining the body’s water balance.
- 6 coenzymes: They accelerate biochemical processes and promote tissue regeneration.
- 5 Nucleic acids: Regulate protein synthesis and, consequently, skin regeneration.
- 2 Reducing agents: Protect skin cells from free radicals and support the skin's structure.
- 23 amino acids: building blocks for important skin proteins such as collagen and elastin.
Mesotherapy is gentle, virtually painless, and, when performed correctly, delivers quick, visible, and long-lasting results—all without any significant downtime.
Areas of Application – Where Is Mesotherapy Used?
Mesotherapy is particularly versatile and offers innovative treatment options in both aesthetic medicine and traditional and therapeutic medicine. Thanks to new studies and scientific findings, its range of applications is constantly expanding. Here is an overview of the most important areas of application:
Skin rejuvenation and skin tightening
Microinjections containing a highly effective blend of hyaluronic acid, vitamins, and antioxidants improve skin texture, boost elasticity, and restore the skin’s natural radiance. Fine lines and early wrinkles can be effectively smoothed out.
According to a study, NCTF 135 HA was shown to improve skin texture: After three treatments, wrinkle depth was visibly reduced, and the skin appeared more radiant and significantly better hydrated. A significant increase in skin moisture was observed as early as seven days after the last injection. The participants’ self-esteem also increased measurably. Tolerability was excellent; side effects were mostly mild and subsided within 48 hours.
Reduction of dark circles and fine lines
Mesotherapy can be particularly effective in the delicate area around the eyes, helping to lighten dark circles, smooth fine lines, and revitalize the skin—for a fresher, more alert appearance.
After just a few sessions of mesotherapy with NCTF 135 HA, crow’s feet can be significantly reduced by up to 43%. Skin tone also appears more even and brighter, which leads to a visibly fresher and more balanced eye area, particularly in cases of pigment-related dark circles.
Hair growth promotion
The effectiveness of mesotherapy has also been studied and confirmed in cases of hair loss: By delivering nutrients directly to the hair follicles, hair growth can be stimulated and hair loss effectively reduced.
Treatment of Scars and Pigmentation Disorders
Thanks to its regenerative effects, mesotherapy is successfully used to gently improve acne scars, minor pigmentation issues, and uneven skin texture.
By promoting collagen production, skin cell proliferation, and skin density, NCTF 135 HA not only reduces wrinkles but also visibly improves skin texture and uniformity. As a result, mesotherapy with NCTF 135 HA is also ideal for treating small scars and pigmentation disorders.
Other interesting medical approaches
For the sake of completeness, we would of course like to share with you other important medical applications of mesotherapy.
Joint therapy (e.g., knee osteoarthritis)
Mesotherapy can also be an effective alternative to conventional methods for treating knee osteoarthritis (gonarthrosis)—resulting in significant pain relief and improved mobility.
Immunomodulation in Allergies and Infections
A special form of mesotherapy (meso-vaccination) is even said to be able to effectively modulate the immune system. This could, for example, significantly reduce susceptibility to infections and hay fever symptoms.
Treatment of bone marrow edema
Mesotherapy is also being used on an experimental basis to provide significant pain relief and reduce bone marrow edema—with demonstrable improvement visible on MRI scans.
Facial Mesotherapy: Procedure and Effects
Facial mesotherapy is a gentle, minimally invasive method for revitalizing the skin long-term and reducing the signs of aging—without surgery or extended downtime.
The Mesotherapy Procedure for the Face
1. Consultation and skin analysis
Before treatment, a detailed analysis of the skin’s structure and individual condition is performed. Based on this analysis, a customized treatment plan is developed that specifically addresses the skin’s needs.
2. Preparing the skin
The skin is thoroughly cleansed. An anesthetic cream may be applied to enhance comfort during the treatment.
3. Injection of the active ingredients
Precise microinjections deliver a special combination of active ingredients directly into the middle layers of the skin. Areas that are particularly prone to aging, such as the forehead, cheeks, and the eye and lip areas, are targeted for treatment.
4. Follow-up care
Mild redness or swelling may occur immediately after treatment, but these symptoms usually subside within a short time. Avoiding direct sunlight and using a moisturizing product will help promote optimal healing.
Effects of Mesotherapy
→A fresh and radiant complexion
After just a few weeks, the skin appears visibly smoother, more even, and more radiant. The complexion looks fresher and gains a new radiance.
→Strengthening the skin's structure
By specifically stimulating the body's own production of collagen and elastin, fine lines are smoothed out and skin density is improved.
→Long-term skin rejuvenation
Mesotherapy provides lasting benefits for skin quality by specifically promoting cell regeneration and hydration—resulting in a healthier, more youthful complexion with a significant reduction in wrinkle depth, increased dermal density, and a visible improvement in skin texture after several sessions.
Cost of Mesotherapy
The cost of mesotherapy depends on various factors, including the size of the treatment area, the number of sessions required, and the combinations of active ingredients used.
On average, prices per session range from €250 to €400, depending on the region and clinic. For optimal results, three to five sessions spaced about two to four weeks apart are often recommended. Many providers also offer package deals for full treatment cycles. At Kalia Lab, you can enjoy the many benefits of this therapy starting at just €379.
It is important to note that the quality and experience of the treating specialist should always be the top priority when choosing a provider. Personalized consultation, high-quality products such as NCTF 135 HA, and precise application are absolutely crucial for safe and long-lasting results.
The Benefits of Mesotherapy at a Glance
Mesotherapy offers a wide range of benefits, particularly in the area of skin and hair regeneration:
- Natural skin rejuvenation: Through the targeted injection of hyaluronic acid, vitamins, and antioxidants, skin texture is improved, wrinkles are smoothed out, and the skin takes on a visibly firmer, fresher appearance.
- Intensive hydration: The skin is hydrated from within, reducing fine lines caused by dryness and restoring the skin’s natural glow
- Improved skin appearance: Imperfections such as pigmentation issues or small scars can be visibly reduced thanks to the regenerative effects of mesotherapy.
- Promoting hair growth: In cases of hair loss, mesotherapy supports hair growth by strengthening the hair follicles and providing the scalp with an optimal supply of nutrients.
- Minimal downtime: The treatment is gentle and does not require a long recovery period. Mild redness usually subsides within a few hours to a few days.
- Long-term results: Several studies show that skin density, elasticity, and hydration can be improved over the long term—resulting in a younger and healthier appearance.
Potential side effects of facial mesotherapy
Mesotherapy is generally considered a very safe treatment, especially when performed by experienced professionals. However, as with all minimally invasive procedures, temporary side effects may occur. Typical, harmless reactions include:
Common: Redness
Mild redness at the injection sites is common and usually subsides within a few hours or, at most, one to two days.
Occasionally: swelling
Minor swelling or a feeling of tightness may occur, but these symptoms will also go away on their own within a short time.
Rare: Bruising
Minor bruising rarely occurs due to minor damage to blood vessels caused by the needle prick, but it usually heals within a few days.
Rare: Sensitivity
You may experience temporary sensitivity or a slight burning sensation in the treated areas, especially if you have sensitive skin.
Serious side effects are extremely rare and can be virtually ruled out by choosing a qualified clinic and using high-quality products such as NCTF 135 HA. Careful aftercare, particularly protection from strong sunlight, promotes quick and uncomplicated healing.
Experiences with facial mesotherapy
Many users report visibly fresher, firmer skin and a more even complexion after mesotherapy. The first positive changes are noticeable after just a few weeks, while the skin’s appearance continues to improve over several months.
A journalist from “Men’s Health” magazine conducted a self-experiment and concluded:
“The very next day, I can already see the first results: My skin looks plumper. Okay, a little red […]. Two days later, everything is back to normal and better than before: My skin is really glowing. Wow! I actually think I look younger. My crow’s feet are much less noticeable, and the nasolabial fold is also less pronounced. Friends I’ve told about the treatment confirm the results.”
Conclusion: Why Mesotherapy Is Worth It
Mesotherapy offers a gentle yet highly effective way to revitalize your skin and hair with long-lasting results. By delivering valuable active ingredients directly to the skin, it supports the skin’s natural regeneration process—with results you can see, feel, and enjoy for years to come.
If you’re looking for natural radiance, firmer skin, and a healthy glow, mesotherapy is the perfect solution—and we’d be happy to guide you through the process!
